In sociological studies, social indifference is one of the main issues in modern societies. This paper is to study the relationship between social indifference and political hope among students. Because political hope is concerned as an important element of any society. In this paper, rational choice theory was used as the theoretical framework. The method of this research was survey. Using a questionnaire, a sample of 400 students from Shiraz University were studied. The sampling method was stratified. Results showed that social indifference among 40.5% of students was higher than average, 27% high, 19% lower than average, and only 13% was low. Also, the results of Pearson correlation test, it was confirmed the relationship of the political hope and its components (believing in getting optimal citizenship rights, believing in the government legitimacy, believing in the possibility of effective political-social participation, being optimistic about the policymaking) with social indifference. Results of multivariate regression analysis, employing step-by-step approach, showed that among the components of political hope, believing in getting optimal citizenship rights, believing in the government legitimacy, and being optimistic about the policymaking explain 15% of social indifference changes.